sms sleep disorder
It is characterized by some major signs such as particular facial features and mild to moderate intellectual disabilities which in turn are usually associated with impaired speech or language skills and sleep or behavior problems. Besides sleep disturbances such as difficulties falling asleep or frequent prolonged nighttime awakenings the common symptoms of SMS include characteristic facial features intellectual disability speech and motor delays and behavioral problems. Prisms Sleep The sleep problems associated with Smith-Magenis syndrome are attributed to haploinsufficiency of the RAI1 gene. . Trouble getting to sleep. The SMS sleep disturbance is likely multifactorial and inversion of melatonin secretion clock genes disturbance phase delay and behavioral insomnia may contribute to sleep disturbance. One consequence of reduced function of RAI1 and characteristic of Smith-Magenis syndrome is an inversion of melatonin secretion resulting in ...